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Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid, taken as a gastro-resistant oral capsule, for the treatment of Familial Adenomatous Polyposis (FAP). Clinical study data demonstrates a significant reduction in rectal polyp number in subjects with familial adenomatous polyposis who had previously undergone colectomy and ileal-rectal anastomosis.